CAS No. 201341-05-1

Batch: Purity:99.94
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Tenofovir Disoproxil Chemical Structure
Chemical Structure
Check the Tenofovir Disoproxil product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(propan-2-yloxycarbonyloxymethoxy)phosphoryl]oxymethyl propan-2-yl carbonate
CAS Number 201341-05-1
Molecular Formula

C19H30N5O10P
Molecular Weight (MW) 519.44
SMILES CC(C)OC(=O)OCO[P](=O)(COC(C)C[N]1C=NC2=C(N)N=CN=C12)OCOC(=O)OC(C)C
InChIKey JFVZFKDSXNQEJW-CQSZACIVSA-N

Ordering Information

Biological Activity

Tenofovir Disoproxil is a prodrug of tenofovir, an acyclic nucleotide phosphonate analog. Intracellularly, it is metabolised to its active anabolite tenofovir diphosphate, which functions as a competitive inhibitor of HIV-1 reverse transcriptase. By competing with natural deoxyribonucleotides, tenofovir diphosphate incorporates into viral DNA and induces DNA chain termination, thereby suppressing viral replication.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (192.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.