CAS No. 906093-29-6

Batch: Purity:99.98
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Teneligliptin hydrobromide Chemical Structure
Chemical Structure
Check the Teneligliptin hydrobromide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name bis([(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone);pentahydrobromide
CAS Number 906093-29-6
Molecular Formula

C22H30N6OS.5/2HBr
Molecular Weight (MW) 628.86
SMILES CC1=NN(C(=C1)N2CCN(CC2)C3CC(NC3)C(=O)N4CCSC4)C5=CC=CC=C5.CC1=NN(C(=C1)N2CCN(CC2)C3CC(NC3)C(=O)N4CCSC4)C5=CC=CC=C5.Br.Br.Br.Br.Br
InChIKey LUXIOMHUGCXFIU-MAYGPZJUSA-N

Ordering Information

Biological Activity

Teneligliptin hydrobromide is a potent and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor with an IC50 of approximately 1 nM against human recombinant, human plasma, and rat plasma DPP-4. By inhibiting DPP-4 enzymatic activity, it prevents the degradation of active glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). This elevation in incretin hormone concentrations enhances glucose-dependent insulin secretion, suppresses glucagon release, and improves glycemic control in preclinical models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (159.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 17 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.