CAS No. 1572583-29-9

Batch: Purity:99.60
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Teneligliptin Hydrobromide Hydrate Chemical Structure
Chemical Structure
Check the Teneligliptin Hydrobromide Hydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name bis([(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone);hydrate;pentahydrobromide
CAS Number 1572583-29-9
Molecular Formula

C22H30N6OS.5/2BrH.xH2O
InChIKey NQPRXLXVOBOTGT-KSLCDFCZSA-N

Biological Activity

Teneligliptin Hydrobromide Hydrate is a potent, competitive dipeptidyl peptidase-4 (DPP-4) inhibitor that inhibits recombinant human DPP-4 (IC50 0.889 nM), human plasma DPP-4 (IC50 1.75 nM), and rat plasma DPP-4 (IC50 1.35 nM). By suppressing DPP-4 activity, it attenuates high glucose-mediated mitochondrial dysfunction and improves glycemic control, serving as a valuable tool for type 2 diabetes research.

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water 100 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.