CAS No. 1639417-53-0

Batch: Purity:99.78
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Tenalisib Chemical Structure
Chemical Structure
Check the Tenalisib product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-(3-fluorophenyl)-2-[(1S)-1-(7H-purin-6-ylamino)propyl]chromen-4-one
CAS Number 1639417-53-0
Molecular Formula

C23H18FN5O2
Molecular Weight (MW) 415.42
SMILES CCC(C1=C(C(=O)C2=CC=CC=C2O1)C3=CC(=CC=C3)F)NC4=NC=NC5=C4NC=N5
InChIKey HDXDQPRPFRKGKZ-INIZCTEOSA-N

Ordering Information

Biological Activity

Tenalisib is a potent and selective dual PI3Kδ/γ inhibitor that targets the delta and gamma isoforms of phosphoinositide 3-kinase. By blocking PI3Kδ and PI3Kγ activity, Tenalisib disrupts downstream AKT/mTOR signaling, leading to reduced cellular proliferation, induced apoptosis, and altered immune cell function within the tumor microenvironment. These actions collectively suppress tumor growth and modulate immune-mediated responses in hematological malignancy models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 50 mg/mL (120.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 14 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.