CAS No. 191729-44-9
Batch:
Purity:99.09
Chemical Structure
Check the
Tenacissoside I
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 191729-44-9 | |
|---|---|---|
| Molecular Formula |
C44H62O14 |
|
| Molecular Weight (MW) | 814.95 | |
| SMILES | CC1C(C(C(C(O1)OC2C(OC(CC2OC)OC3CCC4(C(C3)CCC56C4C(C(C7(C5(O6)CCC7C(=O)C)C)OC(=O)C)OC(=O)C8=CC=CC=C8)C)C)O)OC)O |
Tenacissoside I is a natural C21 steroid isolated from Marsdenia tenacissima that acts as a P-glycoprotein (ABCB1) inhibitor. By suppressing ABCB1-mediated efflux transport, it restores the intracellular accumulation of chemotherapeutic agents and sensitizes multidrug-resistant cancer cells. This activity targets ATP-binding cassette transport pathways to overcome efflux-driven tumor chemoresistance. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(122.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
100 mg/mL
(122.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.