CAS No. 402957-28-2

Batch: Purity:99.82
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Telaprevir (VX-950) Chemical Structure
Chemical Structure
Check the Telaprevir (VX-950) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3S,3aS,6aR)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide
CAS Number 402957-28-2
Molecular Formula

C36H53N7O6
Molecular Weight (MW) 679.85
SMILES CCCC(C(=O)C(=O)NC1CC1)NC(=O)C2C3CCCC3CN2C(=O)C(C(C)(C)C)NC(=O)C(C4CCCCC4)NC(=O)C5=NC=CN=C5
InChIKey BBAWEDCPNXPBQM-GDEBMMAJSA-N

Ordering Information

Biological Activity

Telaprevir (VX-950) is an orally active hepatitis C virus (HCV) NS3-4A serine protease inhibitor. By binding to the catalytic site of the HCV NS3-4A protease complex, Telaprevir blocks the cleavage of viral polyproteins essential for viral replication. This inhibition impairs HCV RNA replication and reduces viral strain propagation in host liver cells. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 136 mg/mL (200.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.