CAS No. 1334719-95-7

Batch: Purity:99.77
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Telacebec Chemical Structure
Chemical Structure
Check the Telacebec product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 6-chloro-2-ethyl-N-[[4-[4-[4-(trifluoromethoxy)phenyl]piperidin-1-yl]phenyl]methyl]imidazo[1,2-a]pyridine-3-carboxamide
CAS Number 1334719-95-7
Molecular Formula

C29H28ClF3N4O2
Molecular Weight (MW) 557.01
SMILES CCC1=C([N]2C=C(Cl)C=CC2=N1)C(=O)NCC3=CC=C(C=C3)N4CCC(CC4)C5=CC=C(OC(F)(F)F)C=C5
InChIKey OJICYBSWSZGRFB-UHFFFAOYSA-N

Ordering Information

Biological Activity

Telacebec (Q203) is an imidazopyridine antituberculosis agent that targets the mycobacterial cytochrome bc1 complex, exhibiting an MIC50 ofagainst Mycobacterium tuberculosis H37Rv in culture broth medium. By binding to the QcrB subunit of the cytochrome bc1 complex, it disrupts electron transport along the respiratory chain, depleting intracellular ATP levels and ultimately impairing mycobacterial cellular energy production. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 20 mg/mL (35.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 20 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.