CAS No. 856867-55-5

Batch: Purity:99.86
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Tedizolid Phosphate Chemical Structure
Chemical Structure
Check the Tedizolid Phosphate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(5R)-3-[3-fluoro-4-[6-(2-methyltetrazol-5-yl)-3-pyridinyl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl dihydrogen phosphate
CAS Number 856867-55-5
Molecular Formula

C17H16FN6O6P
Molecular Weight (MW) 450.32
SMILES CN1N=C(N=N1)C2=NC=C(C=C2)C3=C(C=C(C=C3)N4CC(OC4=O)COP(=O)(O)O)F
InChIKey QCGUSIANLFXSGE-GFCCVEGCSA-N

Biological Activity

Tedizolid phosphate is an oxazolidinone-class prodrug that is converted into its active metabolite, tedizolid. Tedizolid acts as a potent protein synthesis inhibitor by binding to the 50S subunit of the bacterial ribosome. This binding disrupts the formation of the 70S initiation complex, thereby suppressing bacterial protein translation. Consequently, this action inhibits bacterial growth and demonstrates antibacterial activity against Gram-positive pathogens. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 22 mg/mL (48.85 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] J. Med. Chem. 2011;54(7):1953-1960.

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Note: Technical data last updated: Sep 1, 2026.