CAS No. 2305936-56-3
Batch:
Purity:99.92
Chemical Structure
Check the
TD-165
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S,4R)-1-[(2S)-2-[11-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]undecanoylamino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide | |
|---|---|---|
| CAS Number | 2305936-56-3 | |
| Molecular Formula |
C46H59N7O8S |
|
| Molecular Weight (MW) | 870.07 | |
| SMILES | CC1=C(SC=N1)C2=CC=C(CNC(=O)C3CC(O)CN3C(=O)C(NC(=O)CCCCCCCCCCNC4=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=CC=C4)C(C)(C)C)C=C2 | |
| InChIKey | KSXVXTSIDVRZBR-IINAPWRYSA-N |
TD-165 is a proteolysis targeting chimera (PROTAC) that acts as a cereblon (CRBN) degrader. The compound incorporates a CRBN ligand binding group linked to a von Hippel-Landau (VHL) binding ligand, facilitating the recruitment of the VHL E3 ubiquitin ligase to target CRBN for proteasomal degradation. This degradation alters E3 ubiquitin ligase complex activity and modulates cellular protein homeostasis. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(114.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.