CAS No. 301305-73-7
Batch:
Purity:99.89
Chemical Structure
Check the
TCS 359
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2-[(3,4-dimethoxybenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide | |
|---|---|---|
| CAS Number | 301305-73-7 | |
| Molecular Formula |
C18H20N2O4S |
|
| Molecular Weight (MW) | 360.43 | |
| SMILES | COC1=C(C=C(C=C1)C(=O)NC2=C(C3=C(S2)CCCC3)C(=O)N)OC | |
| InChIKey | FSPQCTGGIANIJZ-UHFFFAOYSA-N |
Biological Activity
TCS 359 is a potent FLT3 inhibitor that selectively targets FMS-like tyrosine kinase 3 receptor signaling. By inhibiting FLT3 kinase activity, TCS 359 disrupts critical downstream signaling cascades including STAT5, AKT/mTOR, and MAPK/ERK pathways. Consequently, this targeted inhibition suppresses cell proliferation and promotes apoptosis in leukemic cell populations dependent on FLT3 activation for survival. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
15 mg/mL
(41.61 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.