CAS No. 1422955-31-4
Batch:
Purity:99.06
Chemical Structure
Check the
TC-S 7009
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine | |
|---|---|---|
| CAS Number | 1422955-31-4 | |
| Molecular Formula |
C12H6ClFN4O3 |
|
| Molecular Weight (MW) | 308.65 | |
| InChIKey | CDQUJZKBRAFWNG-UHFFFAOYSA-N |
Biological Activity
TC-Sis a potent and selective inhibitor of hypoxia-inducible factor 2α (HIF-2α) that targets the PAS-B domain. By allosterically disrupting HIF-2α heterodimerization with ARNT, TC-Sdecreases DNA-binding activity and reduces downstream HIF-2α target gene expression. Pharmacological inhibition of HIF-2α with TC-S 7009 counteracts transcriptional activation, suppresses SLC7A11 expression, elevates reactive oxygen species levels, and promotes ferroptotic cell death in tumor models. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
62 mg/mL
(200.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.