CAS No. 1082739-92-1
Batch:
Purity:99.75
Chemical Structure
Check the
TC-S 7005
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-(1,3-benzodioxol-5-yl)-N-[(1S)-1-phenylethyl]-[1,2]oxazolo[5,4-c]pyridin-5-amine | |
|---|---|---|
| CAS Number | 1082739-92-1 | |
| Molecular Formula |
C21H17N3O3 |
|
| Molecular Weight (MW) | 359.38 | |
| InChIKey | DAAGOCSHXCDWDY-ZDUSSCGKSA-N |
TC-S 7005 is a potent small-molecule inhibitor of Polo-like kinases (Plks), targeting Plk2, Plk3, and Plk1. By targeting Plk family serine/threonine protein kinases, the compound disrupts Plk-mediated signaling pathways involved in cell cycle progression, spindle assembly, and centriole duplication. Consequently, Plk inhibition impairs cell proliferation and alters downstream target phosphorylation, rendering it a valuable tool for investigating Polo-like kinase functions in cellular regulation. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
72 mg/mL
(200.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.