CAS No. 1292310-49-6
Batch:
Purity:98.65
Chemical Structure
Check the
TBK1/IKKε-IN-2
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-2-(oxan-4-yloxy)benzonitrile | |
|---|---|---|
| CAS Number | 1292310-49-6 | |
| Molecular Formula |
C26H27N5O3 |
|
| Molecular Weight (MW) | 457.52 | |
| SMILES | C1COCCC1OC2=C(C=C(C=C2)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCOCC5)C#N | |
| InChIKey | BWABTWGSXHTHCG-UHFFFAOYSA-N |
TBK1/IKKε-IN-2 is a dual inhibitor targeting TANK-binding kinase 1 (TBK1) and IκB kinase ε (IKKε). By suppressing TBK1 and IKKε kinase activities, it interrupts the phosphorylation and activation of interferon regulatory factor 3 (IRF3) and NF-kB signaling pathways. This downstream inhibition attenuates the expression of type I interferons and pro-inflammatory cytokines, suppressing innate immune responses and inflammatory phenotypes. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
60 mg/mL
(131.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.