CAS No. 948841-07-4
Batch:
Purity:99.01
Chemical Structure
Check the
TB5
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (E)-1-(5-bromothiophen-2-yl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one | |
|---|---|---|
| CAS Number | 948841-07-4 | |
| Molecular Formula |
C15H14BrNOS |
|
| Molecular Weight (MW) | 336.25 | |
| SMILES | CN(C)C1=CC=C(C=C1)C=CC(=O)C2=CC=C(S2)Br | |
| InChIKey | PTLDLBSWTKNYCY-VMPITWQZSA-N |
Biological Activity
TB5 is a potent and selective monoamine oxidase B (MAO-B) inhibitor that demonstrates preferential selectivity over MAO-A. By inhibiting MAO-B, the compound blocks the oxidative deamination of monoamine neurotransmitters, thereby elevating dopamine levels and reducing reactive oxygen species generation. This targeted inhibition suppresses oxidative stress and prevents neurodegeneration in dopaminergic signaling pathways, preserving neuronal viability and function. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
67 mg/mL
(199.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.