CAS No. 89785-84-2
Batch:
Purity:99.77
Chemical Structure
Check the
Tazobactam Sodium
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | sodium (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-4λ6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate | |
|---|---|---|
| CAS Number | 89785-84-2 | |
| Molecular Formula |
C10H12N4O5S.Na |
|
| Molecular Weight (MW) | 323.28 | |
| SMILES | [NaH].CC1(C[N]2C=CN=N2)C(N3C(CC3=O)[S]1(=O)=O)C(O)=O | |
| InChIKey | RFMIKMMOLPNEDG-QVUDESDKSA-M |
Biological Activity
Tazobactam Sodium is a penicillanic acid sulfone β-lactamase inhibitor that acts against class A and class C serine β-lactamases. By forming covalent, irreversible acyl-enzyme intermediates, tazobactam inactivates β-lactamase enzymes and prevents the enzymatic breakdown of co-administered β-lactam antibiotics. This persistent inhibition restores bacterial susceptibility to antibiotics in β-lactamase–producing Gram-negative pathogens, preserving cell wall synthesis inhibition and preventing bacterial survival. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
65 mg/mL
(201.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 65 mg/mL |
| Ethanol | 16 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.