CAS No. 1678515-93-9
Batch:
Purity:98.27
Chemical Structure
Check the
TASIN-30
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1678515-93-9 | |
|---|---|---|
| Molecular Formula |
C18H30N2O3S |
|
| Molecular Weight (MW) | 354.51 |
TASIN-30 is a selective inhibitor of emopamil binding protein (EBP) in the postsqualene cholesterol biosynthesis pathway. By inhibiting EBP-mediated sterol isomerization, it blocks the production of 7-dehydrocholesterol and depletes downstream sterols required for cellular membranes. This disruption impairs lipid raft integrity, increases phospholipid peroxidation, and alters cell death sensitivity, ultimately inducing ferroptosis and apoptosis to suppress tumor cell proliferation.[1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
71 mg/mL
(200.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 17 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.