CAS No. 1661854-97-2
| IUPAC Name | N-[(8S)-4-amino-6-methyl-5-quinolin-3-yl-8,9-dihydropyrimido[5,4-b]indolizin-8-yl]prop-2-enamide | |
|---|---|---|
| CAS Number | 1661854-97-2 | |
| Molecular Formula |
C23H20N6O |
|
| Molecular Weight (MW) | 396.44 | |
| SMILES | CC1=CC(CN2C1=C(C3=C(N=CN=C32)N)C4=CC5=CC=CC=C5N=C4)NC(=O)C=C | |
| InChIKey | MKCYPWYURWOKST-INIZCTEOSA-N |
Zipalertinib (TAS6417) is a selective, wild-type-sparing EGFR inhibitor that potently targets EGFR exon 20 insertion mutations with IC50 values ranging from 1.1 to 8.0 nmol/L. By suppressing mutant EGFR kinase activity, zipalertinib inhibits downstream auto-phosphorylation and blocks activation of AKT and ERK signaling pathways. This pathway blockade inhibits cell proliferation and induces apoptosis in non-small cell lung cancer models expressing EGFR exon 20 insertion mutations. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
79 mg/mL
(199.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 79 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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- zipalertinib (TAS6417) Clinical Trials
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- zipalertinib (TAS6417) Stock Solution
- zipalertinib (TAS6417) Storage
- zipalertinib (TAS6417) Stability
- zipalertinib (TAS6417) Molecular Weight
- zipalertinib (TAS6417) SMILES
- zipalertinib (TAS6417) Chemical Structure (2D and 3D)
- zipalertinib (TAS6417) SDS｜MSDS