CAS No. 1848959-10-3

Batch: Purity:98.63
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TAS4464 Chemical Structure
Chemical Structure
Check the TAS4464 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamoylamino)methyl]oxolan-2-yl]-5-[2-(2-ethoxy-6-fluorophenyl)ethynyl]pyrrolo[2,3-d]pyrimidine
CAS Number 1848959-10-3
Molecular Formula

C21H23FN6O6S
Molecular Weight (MW) 506.51
SMILES CCOC1=CC=CC(=C1C#CC2=C[N](C3OC(CN[S](N)(=O)=O)C(O)C3O)C4=C2C(=NC=N4)N)F
InChIKey TZTRUHFXPVXWRD-QTQZEZTPSA-N

Ordering Information

Biological Activity

TAS4464 is a highly potent and selective inhibitor of NEDD8-activating enzyme. By blocking NEDD8-activating enzyme activity, TAS4464 prevents the neddylation of cullin proteins, thereby inactivating cullin-RING ubiquitin ligases. This impairment disrupts protein homeostasis by causing the accumulation of regulatory substrate proteins, ultimately suppressing cell cycle progression, inhibiting tumor growth, and triggering apoptotic cell death in diverse cancer models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (197.42 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.