CAS No. 733030-01-8

Batch: Purity:99.99
Check CoA
TAS-102 (Trifluridine/Tipiracil Hydrochloride Mixture) Chemical Structure
Chemical Structure
Check the TAS-102 (Trifluridine/Tipiracil Hydrochloride Mixture) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 733030-01-8
Molecular Formula

C10H11F3N2O5.0.5C9H11ClN4O2.0.5HCl
Molecular Weight (MW) 435.76
SMILES Cl.OCC1OC(CC1O)N2C=C(C(=O)NC2=O)C(F)(F)F.OCC3OC(CC3O)N4C=C(C(=O)NC4=O)C(F)(F)F.ClC5=C(CN6CCCC6=N)NC(=O)NC5=O

Ordering Information

Biological Activity

TAS-102 is an antineoplastic agent composed of the antimetabolite trifluridine and the thymidine phosphorylase inhibitor tipiracil hydrochloride. Trifluridine is incorporated into DNA following intracellular phosphorylation, leading to DNA dysfunction and inhibition of cell proliferation, while tipiracil hydrochloride prevents the degradation of trifluridine by thymidine phosphorylase to maintain therapeutic concentrations. This dual action induces cell cycle arrest and apoptosis, suppressing tumor growth in preclinical models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 87 mg/mL (199.65 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 29 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Aliquotting Service

Free Aliquotting Service

Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.

Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.

Jump to

Note: Technical data last updated: Sep 1, 2026.