For research use only.

Catalog No.S7434

12 publications

TAPI-1 Chemical Structure

CAS No. 171235-71-5

TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. TAPI-1 is also an inhibitor of Matrix Metalloproteinase (MMP).

Selleck's TAPI-1 has been cited by 12 publications

2 Customer Reviews

  • (B) Florescent images of EpEX (green) and EpICD (red) in PK-15 cells, which were transfected by pSIN-fEpCAM-mCherry and treated with or without TAPI-1/DAPT. Nuclei were stained by Hoechst 33342 (blue). Scale bar, 25 μm.

    Sci Rep, 2017, 7:46315. TAPI-1 purchased from Selleck.

    (C and D) 16HBE cells were preincubated with EGFR inhibitors and then exposed to THC for 5 min. Activation of ERK (p-ERK) was detected by immunoblotting. Blot is representative of 3 independent experiments.

    Biochim Biophys Acta Gen Subj, 2018, 1862(9):1988-1994. TAPI-1 purchased from Selleck.

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Biological Activity

Description TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. TAPI-1 is also an inhibitor of Matrix Metalloproteinase (MMP).
MMP [5]
In vitro

TAPI-1 prevents unstimulated and PMA-induced release of the soluble forms of TNF-alpha, p60 TNFR, and IL-6R from the monocytic cell line, THP-1, and from human peripheral blood monocytes. TAPI also inhibits LPS-induced shedding of the p60 TNFR and TNF-alpha from monocytes. [1] TAPI-1 inhibits TACE-dependent constitutive release of co-transfected APP(695). [2] TAPI-1 attenuates Ang II-induced EGFR transactivation and cell proliferation in human HSC line LI90. [3] TAPI-1 with the EGFR inhibitor AG1478 exhibits deactivated AREG/EGFR/ERK signaling pathway and reduces pro-inflammatory cytokines release in pSS salivary gland-derived epithelial cells. [4]

Methods Test Index PMID
Western blot
p-EGFR(Y1068) / EGFR / p-AKT / AKT / p-ERK / ERK; 

PubMed: 31426531     

BEAS-2B cells were treated with TAPI-1 (10 µM), a TNF-α converting enzyme (TACE) inhibitor, for 1 h, and then treated with either TNF (100 ng/mL) or epithelial growth factor (EGF, 10 ng/mL) for 15 min. Cell lysates were immunoblotted with the indicated primary antibodies. β-actin was included as a loading control. 



Cell Research:


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  • Cell lines: LI90 cells
  • Concentrations: 20 μM
  • Incubation Time: 60 hours
  • Method:

    Five thousand cells are seeded into each well of 96-well plates and their viability is assessed by CellTiter-Glo Luminescent Cell Viability assay. Upon serum deprivation for 24 h, the cells are treated with Ang II for 60 h with and without pretreatment with each inhibitor and antagonist. The assay substrates are then added to each well on the plate and the samples are evaluated using a luminometer.

    (Only for Reference)

Solubility (25°C)

In vitro DMSO 99 mg/mL (198.15 mM)
Ethanol 99 mg/mL (198.15 mM)
Water 60 mg/mL warmed (120.09 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 499.60


CAS No. 171235-71-5
Storage powder
in solvent
Synonyms N/A

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID