CAS No. 69659-80-9

Batch: Purity:98.61
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Tanshinone IIA sulfonate sodium Chemical Structure
Chemical Structure
Check the Tanshinone IIA sulfonate sodium product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name sodium 1,6,6-trimethyl-10,11-dioxo-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-2-sulfonate
CAS Number 69659-80-9
Molecular Formula

C19H17O6S.Na
Molecular Weight (MW) 396.39
SMILES CC1=C(OC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C)S(=O)(=O)[O-].[Na+]
InChIKey AZEZEAABTDXEHR-UHFFFAOYSA-M

Ordering Information

Biological Activity

Tanshinone IIA sulfonate sodium is a water-soluble derivative of tanshinone IIA that acts as a negative allosteric modulator of the purinergic receptor P2X7. The compound additionally inhibits CYP3A4 enzyme activity and suppresses store-operated Ca2+ entry through store-operated Ca2+ channels via downregulation of TRPC protein expression. These actions attenuate intracellular calcium influx and downstream calcium-dependent signaling cascades involved in cellular responses. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 79 mg/mL (199.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 10 mg/mL
Ethanol 4 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.