CAS No. 75747-14-7

Batch: Purity:99.92
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Tanespimycin (17-AAG) Chemical Structure
Chemical Structure
Check the Tanespimycin (17-AAG) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-enylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate
CAS Number 75747-14-7
Molecular Formula

C31H43N3O8
Molecular Weight (MW) 585.69
SMILES CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC
InChIKey AYUNIORJHRXIBJ-TXHRRWQRSA-N

Ordering Information

Biological Activity

Tanespimycin (17-AAG) is a potent HSP90 inhibitor that binds to the ATP-binding pocket of HSP90 and alters its chaperone function, exhibiting approximately 100-fold higher affinity for HSP90 derived from tumor cells compared to normal cells. By disrupting HSP90 complexes, tanespimycin promotes the degradation of client proteins, inhibits AKT activation, and induces apoptosis, autophagy, and cell cycle arrest. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (170.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 33 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.