CAS No. 2460722-04-5

Batch: Purity:99.78
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TAK-861 (Oveporexton) Chemical Structure
Chemical Structure
Check the TAK-861 (Oveporexton) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[(2S,3R)-2-[[3-(3,5-difluorophenyl)-2-fluorophenyl]methyl]-4,4-difluoro-1-(2-hydroxy-2-methylpropanoyl)pyrrolidin-3-yl]ethanesulfonamide
CAS Number 2460722-04-5
Molecular Formula

C23H25F5N2O4S
Molecular Weight (MW) 520.52
InChIKey KVMGAIOTUIGROS-AZUAARDMSA-N

Biological Activity

Oveporexton (TAK-861) is a potent, orally bioavailable orexin receptor 2 (OX2R) agonist with an EC50 ofin calcium mobilization assays. Activation of OX2R stimulates intracellular calcium signaling pathways involved in central sleep-wake regulation. In histaminergic neurons of the mouse tuberomammillary nucleus, OX2R activation induces dose-dependent membrane depolarization with an EC50 of, promoting neuronal excitability and wakefulness-promoting networks. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (192.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Nagahara T, et al. J Med Chem. 2015;58(20):7931-7.

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Note: Technical data last updated: Sep 1, 2026.