CAS No. 1450833-55-2
Batch:
Purity:99.61
Chemical Structure
Check the
TAK-243 (MLN7243)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [(1R,2R,3S,4R)-2,3-dihydroxy-4-[[2-[3-(trifluoromethylsulfanyl)phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]amino]cyclopentyl]methyl sulfamate | |
|---|---|---|
| CAS Number | 1450833-55-2 | |
| Molecular Formula |
C19H20F3N5O5S2 |
|
| Molecular Weight (MW) | 519.52 | |
| SMILES | N[S;v6](=O)(=O)OCC1CC(NC2=CC=NC3=CC(=N[N]23)C4=CC(=CC=C4)SC(F)(F)F)C(O)C1O | |
| InChIKey | KJDAGXLMHXUAGV-DGWLBADLSA-N |
TAK-243 (MLN7243) is a potent, mechanism-based small-molecule inhibitor of ubiquitin-activating enzyme (UAE). By blocking UAE-dependent ubiquitination, TAK-243 disrupts protein homeostasis and inhibits downstream ubiquitination cascades. This target inhibition leads to the accumulation of unfolded proteins, induction of endoplasmic reticulum (ER) stress, abrogation of NF-kB pathway activation, and ultimate promotion of apoptosis in cancer cells. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(192.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 25 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(192.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(192.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 25 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(192.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- TAK-243 (MLN7243) Mechanism of Action: UBA1 Inhibition in Leukemia Cell Research
- TAK-243 (MLN7243) Clinical Trials
- TAK-243 (MLN7243) Working Concentration | Cell Culture | Treatment
- TAK-243 (MLN7243) Solubility in DMSO
- TAK-243 (MLN7243) Stock Solution
- TAK-243 (MLN7243) Storage
- TAK-243 (MLN7243) Stability
- TAK-243 (MLN7243) Combination Database
- TAK-243 (MLN7243) Molecular Weight
- TAK-243 (MLN7243) SMILES
- TAK-243 (MLN7243) Chemical Structure (2D and 3D)
- TAK-243 (MLN7243) IC50 for Cell-based and Cell-free Assays
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- TAK-243 (MLN7243) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.