CAS No. 1238697-26-1
Batch:
Purity:99.11
Chemical Structure
Check the
TAK-063
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-(2-fluoro-4-pyrazol-1-ylphenyl)-5-methoxy-3-(2-phenylpyrazol-3-yl)pyridazin-4-one | |
|---|---|---|
| CAS Number | 1238697-26-1 | |
| Molecular Formula |
C23H17FN6O2 |
|
| Molecular Weight (MW) | 428.42 | |
| SMILES | COC1=CN(N=C(C1=O)C2=CC=NN2C3=CC=CC=C3)C4=C(C=C(C=C4)N5C=CC=N5)F | |
| InChIKey | KVHRYLNQDWXAGI-UHFFFAOYSA-N |
TAK-063 (Balipodect) is a selective phosphodiesterase 10A (PDE10A) inhibitor (IC50 0.30 nM). By inhibiting PDE10A, TAK-063 elevates intracellular levels of cAMP and cGMP in striatal medium spiny neurons. This activation regulates both direct and indirect striatal signaling pathways, enhancing corticostriatal functional connectivity and improving cognitive and behavioral deficits in preclinical models of neurological disorders.
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
85 mg/mL
(198.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.