CAS No. 2460249-19-6

Batch: Purity:99.78
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Tagtociclib (PF-07104091) Chemical Structure
Chemical Structure
Check the Tagtociclib (PF-07104091) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(1R,3S)-3-[3-[[3-(methoxymethyl)-1-methylpyrazole-5-carbonyl]amino]-1H-pyrazol-5-yl]cyclopentyl] N-propan-2-ylcarbamate
CAS Number 2460249-19-6
Molecular Formula

C19H28N6O4
Molecular Weight (MW) 404.46
InChIKey MTNBRBDFNSGQKB-GXTWGEPZSA-N

Ordering Information

Biological Activity

Tagtociclib (PF-07104091) is a potent inhibitor targeting cyclin-dependent kinase 2 (CDK2). By selectively inhibiting CDK2 activity, Tagtociclib disrupts cell cycle progression through the G1/S phase transition and impairs downstream proliferative signaling pathways. Consequently, blockade of CDK2 function leads to robust cell cycle arrest, suppression of tumor cell proliferation, and the induction of apoptosis in susceptible cancer cells. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 81 mg/mL (200.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 81 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.