CAS No. 951395-08-7
Batch:
Purity:99.56
Chemical Structure
Check the
Tafamidis meglumine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid;(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol | |
|---|---|---|
| CAS Number | 951395-08-7 | |
| Molecular Formula |
C14H7Cl2NO3.C7H17NO5 |
|
| Molecular Weight (MW) | 503.33 | |
| InChIKey | DQJDBUPLRMRBAB-WZTVWXICSA-N |
Tafamidis meglumine is a transthyretin (TTR) kinetic stabilizer that binds selectively to the unoccupied thyroxine-binding sites of the native TTR tetramer. By stabilizing the native tetrameric structure, it effectively prevents tetramer dissociation into monomeric subunits, inhibiting subsequent protein misfolding and aggregation into cytotoxic amyloid fibrils associated with transthyretin familial amyloid polyneuropathy. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
25 mg/mL
(49.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.