CAS No. 206658-92-6

Batch: Purity:97
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Tacrine hydrochloride hydrate Chemical Structure
Chemical Structure
Check the Tacrine hydrochloride hydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1,2,3,4-tetrahydroacridin-9-amine;hydrate;hydrochloride
CAS Number 206658-92-6
Molecular Formula

C13H14N2.xHCl.xH2O
Molecular Weight (MW) 198.26(free bases)
SMILES C1CCC2=NC3=CC=CC=C3C(=C2C1)N.O.Cl
InChIKey PXGRMZYJAOQPNZ-UHFFFAOYSA-N

Ordering Information

Biological Activity

Tacrine hydrochloride hydrate is a centrally active cholinesterase inhibitor that targets acetylcholinesterase and butyrylcholinesterase. By blocking the enzymatic degradation of acetylcholine within the central nervous system, it elevates synaptic acetylcholine levels, enhances cholinergic neurotransmission, and modulates downstream cholinergic signaling pathways. Additionally, Tacrine functions as a histamine N-methyltransferase inhibitor, altering histamine metabolism and neurotransmitter balance. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 50 mg/mL
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water 50 mg/mL
Ethanol 50 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.