CAS No. 1684-40-8
Batch:
Purity:99.98
Chemical Structure
Check the
Tacrine HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 1,2,3,4-tetrahydroacridin-9-amine;hydrochloride | |
|---|---|---|
| CAS Number | 1684-40-8 | |
| Molecular Formula |
C13H14N2.HCl |
|
| Molecular Weight (MW) | 234.72 | |
| SMILES | C1CCC2=NC3=CC=CC=C3C(=C2C1)N.Cl | |
| InChIKey | ZUFVXZVXEJHHBN-UHFFFAOYSA-N |
Biological Activity
Tacrine HCl is a centrally acting anticholinesterase and indirect cholinergic agonist that functions as a potent dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). By inhibiting the enzymatic degradation of acetylcholine, it increases synaptic acetylcholine concentrations, thereby enhancing central cholinergic neurotransmission and downstream neuronal signaling cascades involved in cognitive function and synaptic plasticity.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
46 mg/mL
(195.97 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 46 mg/mL |
| Ethanol | 46 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.