CAS No. 1784751-18-3
Batch:
Purity:99.84
Chemical Structure
Check the
TA-01
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[2-(2,6-difluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyridine | |
|---|---|---|
| CAS Number | 1784751-18-3 | |
| Molecular Formula |
C20H12F3N3 |
|
| Molecular Weight (MW) | 351.32 | |
| SMILES | C1=CC(=C(C(=C1)F)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)F | |
| InChIKey | TWPJJJZCYVFUOA-UHFFFAOYSA-N |
TA-01 is a potent small-molecule inhibitor targeting casein kinase 1 epsilon (CK1ε), casein kinase 1 delta (CK1δ), and p38 mitogen-activated protein kinase (p38 MAPK). By inhibiting CK1 and p38 MAPK enzymatic activities, TA-01 modulates key intracellular signaling cascades, including the Wnt/β-catenin and p38 MAPK pathways. These actions influence downstream cellular phenotypes, such as cell survival, proliferation, and stem cell differentiation responses involved in lineage commitment and stress signaling. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
20 mg/mL
(56.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.