CAS No. 530141-72-1
| IUPAC Name | 3-[5-(4-cyclopentyloxy-2-hydroxybenzoyl)-2-[(3-oxo-1,2-benzoxazol-6-yl)methoxy]phenyl]propanoic acid | |
|---|---|---|
| CAS Number | 530141-72-1 | |
| Molecular Formula |
C29H27NO8 |
|
| Molecular Weight (MW) | 517.53 | |
| SMILES | C1CCC(C1)OC2=CC(=C(C=C2)C(=O)C3=CC(=C(C=C3)OCC4=CC5=C(C=C4)C(=O)NO5)CCC(=O)O)O | |
| InChIKey | DALCQQSLNPLQFZ-UHFFFAOYSA-N |
T-5224 is a selective c-Fos/activator protein-1 (AP-1) transcription factor inhibitor with anti-inflammatory properties. It specifically inhibits the DNA-binding activity of the c-Fos/c-Jun heterodimer complex. By suppressing AP-1 transcriptional activity, T-5224 blocks IL-1β-induced upregulation of matrix metalloproteinases, including Mmp-3 and Mmp-13, as well as Adamts-5. Consequently, this downregulation attenuates inflammatory signaling pathways, matrix degradation, and joint destruction in arthritis models.
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(193.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(193.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(193.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(193.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(193.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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- T-5224 Mechanism of Action: c-Fos Inhibition in Tumor Cell Research
- T-5224 Working Concentration | Cell Culture | Treatment
- T-5224 Solubility in DMSO
- T-5224 Stock Solution
- T-5224 Storage
- T-5224 Stability
- T-5224 Combination Database
- T-5224 Molecular Weight
- T-5224 SMILES
- T-5224 Chemical Structure (2D and 3D)
- T-5224 IC50 for Cell-based and Cell-free Assays
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- T-5224 SDS｜MSDS