CAS No. 1422535-52-1
Batch:
Purity:99.80
Chemical Structure
Check the
T-3775440 HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[4-[(1S,2R)-2-(cyclopropylmethylamino)cyclopropyl]phenyl]-1-methylpyrazole-4-carboxamide;hydrochloride | |
|---|---|---|
| CAS Number | 1422535-52-1 | |
| Molecular Formula |
C18H23ClN4O |
|
| Molecular Weight (MW) | 346.85 | |
| SMILES | CN1C=C(C=N1)C(=O)NC2=CC=C(C=C2)C3CC3NCC4CC4.Cl | |
| InChIKey | XYFPAGOQZFSLFH-MCJVGQIASA-N |
T-3775440 HCl is a potent, irreversible inhibitor of LSD1 (IC50 = 2.1 nmol/L) displaying high selectivity over monoamine oxidases MAO-A and MAO-B. By blocking LSD1-mediated histone demethylation, the compound alters epigenetic signaling and restores transcriptional activity of target genes. This downstream mechanism inhibits cell proliferation while inducing differentiation and apoptosis in acute myeloid leukemia cell lines.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
69 mg/mL
(198.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 22 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.