CAS No. 869296-13-9
Batch:
Purity:99.75
Chemical Structure
Check the
T-26c
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[[2-[(3-methoxyphenyl)methylcarbamoyl]-4-oxo-3H-thieno[2,3-d]pyrimidin-5-yl]methoxymethyl]benzoic acid | |
|---|---|---|
| CAS Number | 869296-13-9 | |
| Molecular Formula |
C24H21N3O6S |
|
| Molecular Weight (MW) | 479.51 | |
| SMILES | COC1=CC=CC(=C1)CNC(=O)C2=NC3=C(C(=CS3)COCC4=CC=C(C=C4)C(=O)O)C(=O)N2 | |
| InChIKey | CDQRIIUMNLMHRH-UHFFFAOYSA-N |
T-26c is a potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor. MMP-13 plays a critical role in extracellular matrix remodeling by degrading type II collagen within articular cartilage, driving joint degeneration and osteoarthritis progression. Targeted inhibition of MMP-13 blocks collagen cleavage, preserving extracellular matrix architecture and mitigating cartilage erosion in osteoarthritic tissue models. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
40 mg/mL
(83.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.