CAS No. 84-36-6

Batch: Purity:99.51
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Syrosingopine (SU 3118) Chemical Structure
Chemical Structure
Check the Syrosingopine (SU 3118) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name methyl (1R,15S,17R,18R,19S,20S)-17-(4-ethoxycarbonyloxy-3,5-dimethoxybenzoyl)oxy-6,18-dimethoxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
CAS Number 84-36-6
Molecular Formula

C35H42N2O11
Molecular Weight (MW) 666.71
SMILES CCOC(=O)OC1=C(OC)C=C(C=C1OC)C(=O)OC2CC3CN4CCC5=C([NH]C6=C5C=CC(=C6)OC)C4CC3C(C2OC)C(=O)OC
InChIKey ZCDNRPPFBQDQHR-SSYATKPKSA-N

Ordering Information

Biological Activity

Syrosingopine is an antihypertensive derivative that acts as a dual monocarboxylate transporter 1 (MCT1) and monocarboxylate transporter 4 (MCT4) inhibitor. By blocking MCT1- and MCT4-mediated lactate efflux, syrosingopine causes intracellular lactic acid accumulation and disrupts glycolytic flux. This inhibition impairs cellular ATP production and essential metabolic pathways, ultimately triggering cell death and sensitizing cancer cells to metabolic disruption. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (149.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 5 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.