CAS No. 2417302-07-7
Batch:
Purity:99.57
Chemical Structure
Check the
SY-5609
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 7-dimethylphosphoryl-3-[2-[[(3S)-6,6-dimethylpiperidin-3-yl]amino]-5-(trifluoromethyl)pyrimidin-4-yl]-1H-indole-6-carbonitrile | |
|---|---|---|
| CAS Number | 2417302-07-7 | |
| Molecular Formula |
C23H26F3N6OP |
|
| Molecular Weight (MW) | 490.46 | |
| InChIKey | JDJOUBVVSQDIRC-AWEZNQCLSA-N |
SY-5609 is an orally active and highly selective inhibitor of cyclin-dependent kinase 7 (CDK7) with sub-nanomolar binding affinity (sub-nM KD). By inhibiting CDK7 in both the CDK-activating kinase (CAK) and TFIIH complexes, SY-5609 suppresses transcription and disrupts cell cycle control. These molecular effects lead to downstream cellular responses, including inhibition of cancer cell proliferation, cell cycle arrest, and induction of apoptosis. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
98 mg/mL
(199.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 98 mg/mL |
| Water | Insoluble |
| DMSO |
14 mg/mL
(28.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.