CAS No. 6991-10-2
Batch:
Purity:99.70
Chemical Structure
Check the
Swertisin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one | |
|---|---|---|
| CAS Number | 6991-10-2 | |
| Molecular Formula |
C22H22O10 |
|
| Molecular Weight (MW) | 446.4 | |
| InChIKey | ABRULANJVVJLFI-DGHBBABESA-N |
Swertisin is a C-glucosylflavone that functions as an antagonist of the adenosine A1 receptor and an inhibitor of sodium-glucose cotransporter 2 (SGLT2). Antagonism of adenosine A1 receptors promotes PKA and CREB signaling to mitigate cognitive impairment. Additionally, swertisin inhibits SGLT2 to enhance glucose homeostasis and suppresses hepatitis B virus (HBV) replication by reducing levels of HBsAg, HBeAg, and viral DNA. [1][2][3]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
89 mg/mL
(199.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.