CAS No. 94055-76-2

Batch: Purity:99.98
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Suplatast Tosylate Chemical Structure
Chemical Structure
Check the Suplatast Tosylate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [3-[4-(3-ethoxy-2-hydroxypropoxy)anilino]-3-oxopropyl]-dimethylsulfanium;4-methylbenzenesulfonate
CAS Number 94055-76-2
Molecular Formula

C23H33NO7S2
Molecular Weight (MW) 499.64
SMILES CCOCC(COC1=CC=C(C=C1)NC(=O)CC[S+](C)C)O.CC1=CC=C(C=C1)S(=O)(=O)[O-]
InChIKey RYVJQEZJUFRANT-UHFFFAOYSA-N

Ordering Information

Biological Activity

Suplatast tosylate is a Th2 cytokine inhibitor that selectively suppresses interleukin-4 (IL-4) and interleukin-5 (IL-5) synthesis with an IC50 greater than. By inhibiting Th2-mediated cytokine production without directly impacting B cell function, this agent decreases IgE synthesis, suppresses local eosinophil accumulation, and reduces infiltration of CD4+ T cells into the airways, ultimately alleviating allergen-induced airway hyperresponsiveness. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (200.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 100 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.