CAS No. 2370013-12-8

Batch: Purity:99.41
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Sunvozertinib Chemical Structure
Chemical Structure
Check the Sunvozertinib product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[5-[[4-[5-chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide
CAS Number 2370013-12-8
Molecular Formula

C29H35ClFN7O3
Molecular Weight (MW) 584.09
InChIKey BTMKEDDEMKKSEF-QGZVFWFLSA-N

Biological Activity

Sunvozertinib (DZD9008) is an oral, potent, and selective ErbB family tyrosine kinase inhibitor targeting EGFR and HER2 mutants. It effectively inhibits wild-type EGFR as well as oncogenic mutations, including EGFR exon 20 insertions and HER2 exon 20 insertions. By disrupting ErbB receptor phosphorylation, sunvozertinib blocks downstream RAS/RAF/MEK/ERK and PI3K/AKT/mTOR signaling pathways, leading to the inhibition of cancer cell proliferation and survival.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (171.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 25 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.