Numerous clinical trials evaluate sunitinib malate across early to late phases for oncology indications—including renal cell carcinoma, gastrointestinal stromal tumors, papillary renal cell carcinoma, non-GIST sarcomas, and pediatric central nervous system tumors—as well as non-oncology conditions such as neovascular age-related macular degeneration. Sponsored by academic centers, government entities such as the National Cancer Institute, and industry sponsors including Pfizer and AstraZeneca, these studies encompass completed, recruiting, active not recruiting, and not yet recruiting statuses.
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT00329043 | ACTIVE_NOT_RECRUITING | Prostate Cancer |
M.D. Anderson Cancer Center |
2006-05-15 | PHASE2 |
| NCT03541902 | ACTIVE_NOT_RECRUITING | Malignant Neoplasms of Urinary Tract; Renal Cell Carcinoma; Chromophobe Renal Cell Carcinoma; Metastatic Renal Cell Carcinoma; Papillary Renal Cell Carcinoma; Renal Cell Carcinoma Associated With Xp11.2 Translocations/TFE3 Gene Fusions; Sarcomatoid Renal Cell Carcinoma; Stage IV Renal Cell Cancer AJCC v8; Unclassified Renal Cell Carcinoma |
M.D. Anderson Cancer Center |
2018-05-15 | PHASE2 |
| NCT02068586 | ACTIVE_NOT_RECRUITING | Ciliary Body and Choroid Melanoma, Medium/Large Size; Ciliary Body and Choroid Melanoma, Small Size; Iris Melanoma; Stage I Intraocular Melanoma; Stage IIA Intraocular Melanoma; Stage IIB Intraocular Melanoma; Stage IIIA Intraocular Melanoma; Stage IIIB Intraocular Melanoma; Stage IIIC Intraocular Melanoma; Stage I Uveal Melanoma AJCC V7; Stage II Uveal Melanoma AJCC V7; Stage III Uveal Melanoma AJCC V7 |
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University |
2014-11-19 | PHASE2 |
| NCT02465060 | ACTIVE_NOT_RECRUITING | Advanced Lymphoma; Advanced Malignant Solid Neoplasm; Bladder Carcinoma; Breast Carcinoma; Cervical Carcinoma; Colon Carcinoma; Colorectal Carcinoma; Endometrial Carcinoma; Esophageal Carcinoma; Exocrine Pancreas Carcinoma; Gastric Carcinoma; Glioma; Head and Neck Carcinoma; Hematopoietic and Lymphoid Cell Neoplasm; Kidney Carcinoma; Liver Carcinoma; Lung Carcinoma; Lymphoma; Malignant Uterine Corpus Neoplasm; Malignant Uterine Neoplasm; Melanoma; Multiple Myeloma; Ovarian Carcinoma; Prostate Carcinoma; Rectal Carcinoma; Recurrent Bladder Carcinoma; Recurrent Breast Carcinoma; Recurrent Cervical Carcinoma; Recurrent Colon Carcinoma; Recurrent Colorectal Carcinoma; Recurrent Esophageal Carcinoma; Recurrent Gastric Carcinoma; Recurrent Glioma; Recurrent Head and Neck Carcinoma; Recurrent Liver Carcinoma; Recurrent Lung Carcinoma; Recurrent Lymphoma; Recurrent Malignant Solid Neoplasm; Recurrent Malignant Uterine Corpus Neoplasm; Recurrent Melanoma; Recurrent Multiple Myeloma; Recurrent Ovarian Carcinoma; Recurrent Pancreatic Carcinoma; Recurrent Prostate Carcinoma; Recurrent Rectal Carcinoma; Recurrent Skin Carcinoma; Recurrent Thyroid Gland Carcinoma; Refractory Lymphoma; Refractory Malignant Solid Neoplasm; Refractory Multiple Myeloma; Skin Carcinoma; Thyroid Gland Carcinoma |
National Cancer Institute (NCI) |
2015-08-17 | PHASE2 |
| NCT05678673 | ACTIVE_NOT_RECRUITING | Non-Clear Cell Renal Cell Carcinoma |
Exelixis |
2023-01-01 | PHASE3 |
| NCT05687123 | RECRUITING | Metastatic Pancreatic Neuroendocrine Tumor; Pancreatic Neoplasm; Stage III Pancreatic Neuroendocrine Tumor AJCC v8; Stage IV Pancreatic Neuroendocrine Tumor AJCC v8; Unresectable Pancreatic Neuroendocrine Tumor |
National Cancer Institute (NCI) |
2024-08-14 | PHASE1 |
| NCT03463460 | ACTIVE_NOT_RECRUITING | Thymic Carcinoma |
Dwight Owen |
2018-06-19 | PHASE2 |
| NCT06222593 | Not yet recruiting | Carcinoma Renal Cell |
State University of New York at Buffalo |
2024-06-01 | Phase 1|Phase 2 |
| NCT06208748 | Not yet recruiting | Gastrointestinal Stromal Tumors|GIST |
Sarcoma Alliance for Research through Collaboration|Cogent Biosciences Inc.|Dana-Farber Cancer Institute|The Life Raft Group |
2024-03 | Phase 2 |
| NCT02761057 | COMPLETED | Locally Advanced Papillary Renal Cell Carcinoma; Metastatic Papillary Renal Cell Carcinoma; Stage III Renal Cell Cancer AJCC v7; Stage IV Renal Cell Cancer AJCC v7; Type 1 Papillary Renal Cell Carcinoma; Type 2 Papillary Renal Cell Carcinoma; Unresectable Renal Cell Carcinoma |
National Cancer Institute (NCI) |
2016-07-25 | PHASE2 |
| NCT00813423 | COMPLETED | Adult Solid Neoplasm |
National Cancer Institute (NCI) |
2010-02-19 | PHASE1 |
| NCT05745142 | Completed | Carcinoma Renal Cell|Clear-cell Metastatic Renal Cell Carcinoma |
Pfizer |
2023-02-23 | -- |
| NCT05043090 | Recruiting | Papillary Renal Cell Carcinoma |
AstraZeneca |
2021-10-28 | Phase 3 |
| NCT03909724 | UNKNOWN | Colorectal Cancer; Metastasis |
Amsterdam UMC, location VUmc |
2019-10-01 | PHASE2; PHASE3 |
| NCT04669366 | Completed | Kidney Neoplasms |
Pfizer |
2021-01-20 | -- |
| NCT03953079 | COMPLETED | Neovascular Age-Related Macular Degeneration |
Graybug Vision |
2019-09-26 | PHASE2 |
| NCT01664182 | COMPLETED | Advanced Renal Cell Carcinoma; Advanced Sarcomatoid Renal Cell Carcinoma; Stage III Renal Cell Cancer AJCC v7; Stage IV Renal Cell Cancer AJCC v7 |
National Cancer Institute (NCI) |
2012-08-01 | PHASE2 |
| NCT04085341 | COMPLETED | Diabetic Macular Edema; Retina Vein Occlusion |
Graybug Vision |
2019-09-11 | PHASE2 |
| NCT00478426 | COMPLETED | Endometrial Adenocarcinoma; Endometrial Endometrioid Adenocarcinoma; Endometrial Serous Adenocarcinoma; Recurrent Uterine Corpus Carcinoma; Stage IVA Uterine Corpus Cancer AJCC v7; Stage IVB Uterine Corpus Cancer AJCC v7; Uterine Carcinosarcoma; Uterine Corpus Carcinosarcoma |
National Cancer Institute (NCI) |
2007-04-30 | PHASE2 |
| NCT05800106 | COMPLETED | Gastrointestinal Stromal Tumors; Renal Cell Carcinoma; Pancreatic Neuroendocrine Tumor |
Chia Tai Tianqing Pharmaceutical Group Co., Ltd. |
2018-12-04 | PHASE1 |
| NCT03249740 | COMPLETED | Neovascular Age-Related Macular Degeneration |
Graybug Vision |
2017-08-29 | PHASE1 |
| NCT02779283 | COMPLETED | Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia |
OHSU Knight Cancer Institute |
2016-01-13 | PHASE1 |
| NCT01005472 | COMPLETED | Metastatic Melanoma |
Jonsson Comprehensive Cancer Center |
2008-12-01 | PHASE1 |
| NCT02626754 | TERMINATED | Renal Cell Carcinoma |
vghtpe user |
2015-08-12 | PHASE2 |
| NCT01396148 | COMPLETED | Gastrointestinal Stromal Tumors |
Pfizer |
2012-06 | PHASE2 |
| NCT01164202 | COMPLETED | Liver Cancer |
Federation Francophone de Cancerologie Digestive |
2010-07 | PHASE2; PHASE3 |
| NCT01620216 | TERMINATED | Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome; Chronic Myelomonocytic Leukemia; Recurrent Acute Lymphoblastic Leukemia; Recurrent Acute Myeloid Leukemia; Refractory Acute Lymphoblastic Leukemia; Refractory Acute Myeloid Leukemia |
OHSU Knight Cancer Institute |
2012-05-11 | PHASE2 |
| NCT00381641 | COMPLETED | Differentiated Thyroid Gland Carcinoma; Recurrent Thyroid Gland Carcinoma; Refractory Thyroid Gland Carcinoma; Stage III Thyroid Gland Follicular Carcinoma AJCC v7; Stage III Thyroid Gland Medullary Carcinoma AJCC v7; Stage IV Thyroid Gland Follicular Carcinoma AJCC v7; Stage IV Thyroid Gland Medullary Carcinoma AJCC v7; Stage IV Thyroid Gland Papillary Carcinoma AJCC v7; Stage IVA Thyroid Gland Follicular Carcinoma AJCC v7; Stage IVA Thyroid Gland Medullary Carcinoma AJCC v7; Stage IVA Thyroid Gland Papillary Carcinoma AJCC v7; Stage IVB Thyroid Gland Follicular Carcinoma AJCC v7; Stage IVB Thyroid Gland Medullary Carcinoma AJCC v7; Stage IVB Thyroid Gland Papillary Carcinoma AJCC v7; Stage IVC Thyroid Gland Follicular Carcinoma AJCC v7; Stage IVC Thyroid Gland Medullary Carcinoma AJCC v7; Stage IVC Thyroid Gland Papillary Carcinoma AJCC v7; Thyroid Gland Oncocytic Carcinoma; Unresectable Thyroid Gland Carcinoma |
National Cancer Institute (NCI) |
2006-08-29 | PHASE2 |
| NCT01835158 | COMPLETED | Clear Cell Renal Cell Carcinoma; Metastatic Kidney Carcinoma; Stage III Renal Cell Cancer AJCC v7; Stage IV Renal Cell Cancer AJCC v7 |
National Cancer Institute (NCI) |
2013-07-08 | PHASE2 |
| NCT00375674 | COMPLETED | Kidney Neoplasms |
Pfizer |
2007-08-01 | PHASE3 |
| NCT01525550 | COMPLETED | Well-differentiated Pancreatic Neuroendocrine Tumor |
Pfizer |
2012-06-06 | PHASE4 |
| NCT01061411 | COMPLETED | Clear Cell Sarcoma of the Kidney; Recurrent Renal Cell Carcinoma; Stage III Renal Cell Cancer; Stage IV Renal Cell Cancer |
Roswell Park Cancer Institute |
2010-02-06 | PHASE1 |
| NCT00326898 | COMPLETED | Clear Cell Renal Cell Carcinoma; Stage I Renal Cell Cancer AJCC v6 and v7; Stage II Renal Cell Cancer AJCC v7; Stage III Renal Cell Cancer AJCC v7 |
National Cancer Institute (NCI) |
2006-04-24 | PHASE3 |
| NCT00519896 | COMPLETED | Recurrent Thyroid Cancer; Stage IVA Follicular Thyroid Cancer; Stage IVA Papillary Thyroid Cancer; Stage IVB Follicular Thyroid Cancer; Stage IVB Papillary Thyroid Cancer; Stage IVC Follicular Thyroid Cancer; Stage IVC Papillary Thyroid Cancer; Thyroid Gland Medullary Carcinoma |
University of Washington |
2007-07 | PHASE2 |
| NCT00465179 | COMPLETED | Renal Cell Cancer; Kidney Cancer |
M.D. Anderson Cancer Center |
2007-03 | PHASE2 |
| NCT00631527 | COMPLETED | Prostate Cancer |
M.D. Anderson Cancer Center |
2008-02 | PHASE1 |
| NCT00912912 | TERMINATED | Genitourinary Disease |
M.D. Anderson Cancer Center |
2009-05 | PHASE2 |
| NCT00943839 | COMPLETED | Kidney Cancer |
Centre Antoine Lacassagne |
2009-02 | |
| NCT01089088 | COMPLETED | Bladder Cancer; Transitional Cell Cancer of the Renal Pelvis and Ureter; Urethral Cancer |
Cardiff University |
2009-04 | PHASE2 |
| NCT00428220 | COMPLETED | Metastatic Breast Cancer; Advanced Breast Cancer; Metastatic Castration Resistant Prostate Cancer; Metastatic Renal Cell Cancer; Non-Small Cell Lung Cancer; Thyroid Cancer; Advanced/Metastatic Non-Small Cell Lung Cancer; Advanced Gastric Cancer; Gastrointestinal Stromal Tumor; Hepatocellular Carcinoma; Pancreatic Islet Cell Carcinoma; Pancreatic Neuroendocrine Tumor |
Pfizer |
2007-07 | |
| NCT00463060 | COMPLETED | Cancer |
Icahn School of Medicine at Mount Sinai |
2007-01 | PHASE1; PHASE2 |
| NCT00747305 | TERMINATED | Kidney Cancer |
Harry Drabkin |
2008-10 | PHASE1 |
| NCT00499135 | COMPLETED | Adult Solid Neoplasm; Clear Cell Renal Cell Carcinoma; Recurrent Renal Cell Carcinoma; Stage III Renal Cell Cancer; Stage IV Renal Cell Cancer |
National Cancer Institute (NCI) |
2007-05-22 | PHASE1 |
| NCT00979992 | COMPLETED | Ovarian Clear Cell Adenocarcinoma; Recurrent Ovarian Carcinoma |
National Cancer Institute (NCI) |
2010-04-19 | PHASE2 |
| NCT00793871 | COMPLETED | Gastrointestinal Neoplasms, Gastrointestinal Stromal Tumors |
Pfizer |
2008-11 | PHASE4 |
| NCT01740154 | TERMINATED | Fatigue; Recurrent Renal Cell Cancer; Stage IV Renal Cell Cancer |
Case Comprehensive Cancer Center |
2012-09 | |
| NCT00853125 | TERMINATED | Kidney Cancer |
Rutgers, The State University of New Jersey |
2009-02 | PHASE2 |
| NCT01243359 | COMPLETED | Clear Cell Renal Cell Carcinoma; Recurrent Renal Cell Cancer; Stage I Renal Cell Cancer; Stage II Renal Cell Cancer; Stage III Renal Cell Cancer; Stage IV Renal Cell Cancer; Unspecified Adult Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2010-10 | PHASE1 |
| NCT01462695 | COMPLETED | Childhood Cerebellar Anaplastic Astrocytoma; Childhood Cerebral Anaplastic Astrocytoma; Childhood Cerebral Astrocytoma; Childhood Infratentorial Ependymoma; Childhood Mixed Glioma; Childhood Oligodendroglioma; Childhood Supratentorial Ependymoma; Recurrent Childhood Cerebellar Astrocytoma; Recurrent Childhood Cerebral Astrocytoma; Recurrent Childhood Ependymoma; Recurrent Childhood Subependymal Giant Cell Astrocytoma |
National Cancer Institute (NCI) |
2012-01 | PHASE2 |
| NCT00693992 | COMPLETED | Stage IIIB Lung Non-Small Cell Cancer AJCC v7; Stage IV Non-Small Cell Lung Cancer AJCC v7 |
National Cancer Institute (NCI) |
2008-06-15 | PHASE3 |
| NCT00702884 | COMPLETED | Esophageal Cancer |
Tony Bekaii-Saab |
2008-06-30 | PHASE2 |
| NCT00524186 | TERMINATED | Esophageal Cancer; Gastric Cancer |
Roswell Park Cancer Institute |
2007-05 | PHASE1 |
| NCT00453154 | COMPLETED | Extensive Stage Lung Small Cell Carcinoma; Recurrent Lung Small Cell Carcinoma |
National Cancer Institute (NCI) |
2007-03-15 | PHASE1; PHASE2 |
| NCT01158222 | COMPLETED | Clear Cell Renal Cell Carcinoma; Stage IV Renal Cell Cancer |
Case Comprehensive Cancer Center |
2010-08-18 | PHASE2 |
| NCT00891878 | COMPLETED | Adenocarcinoma of the Gastroesophageal Junction; Esophageal Cancer |
Alliance for Clinical Trials in Oncology |
2009-08 | PHASE2 |
| NCT00489944 | UNKNOWN | Intraocular Melanoma |
San Diego Pacific Oncology & Hematology Associates |
2007-05 | PHASE2 |
| NCT00387920 | COMPLETED | Central Nervous System Metastases; Childhood Central Nervous System Choriocarcinoma; Childhood Central Nervous System Embryonal Tumor; Childhood Central Nervous System Germ Cell Tumor; Childhood Central Nervous System Germinoma; Childhood Central Nervous System Mixed Germ Cell Tumor; Childhood Central Nervous System Teratoma; Childhood Central Nervous System Yolk Sac Tumor; Recurrent Childhood Central Nervous System Embryonal Tumor; Unspecified Childhood Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2006-10 | PHASE1 |
| NCT00672594 | COMPLETED | Prostate Cancer; Prostatectomy |
Duke University |
2006-07 | PHASE2 |
| NCT00906360 | TERMINATED | Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Salivary Gland Squamous Cell Carcinoma; Stage III Salivary Gland Cancer; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IV Salivary Gland Cancer; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IV Verrucous Carcinoma of the Larynx; Stage IV Verrucous Carcinoma of the Oral Cavity; Tongue Cancer; Untreated Metastatic Squamous Neck Cancer With Occult Primary |
National Cancer Institute (NCI) |
2008-07 | PHASE1 |
| NCT00606008 | COMPLETED | Anaplastic Astrocytoma; Glioblastoma |
H. Lee Moffitt Cancer Center and Research Institute |
2007-03 | PHASE2 |
| NCT00513695 | COMPLETED | Inflammatory Breast Cancer; Male Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer |
University of Washington |
2007-06 | PHASE2 |
| NCT00864721 | COMPLETED | Non Small Cell Lung Cancer |
US Oncology Research |
2009-02 | PHASE2 |
| NCT00357318 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2006-06 | PHASE1 |
| NCT01118351 | TERMINATED | Recurrent Bladder Cancer; Transitional Cell Carcinoma of the Bladder |
Case Comprehensive Cancer Center |
2008-10 | PHASE2 |
| NCT00753727 | UNKNOWN | Soft Tissue Sarcoma |
Australasian Sarcoma Study Group |
2008-09 | PHASE1; PHASE2 |
| NCT01258348 | COMPLETED | Metastatic Renal Cell Cancer |
Eli Lilly and Company |
2008-07 | PHASE1 |
| NCT00397488 | COMPLETED | Bladder Cancer; Transitional Cell Cancer of the Renal Pelvis and Ureter; Urethral Cancer |
Memorial Sloan Kettering Cancer Center |
2006-09 | PHASE2 |
| NCT00434109 | COMPLETED | Neuroendocrine Tumor; Islet Cell Tumor |
H. Lee Moffitt Cancer Center and Research Institute |
2006-11 | PHASE2 |
| NCT00910039 | TERMINATED | Cognitive/Functional Effects; Metastatic Cancer; Unspecified Adult Solid Tumor, Protocol Specific |
Case Comprehensive Cancer Center |
2009-04 | PHASE2 |
| NCT00392496 | COMPLETED | Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma |
National Cancer Institute (NCI) |
2007-02 | PHASE2 |
| NCT00388037 | COMPLETED | Recurrent Fallopian Tube Cancer; Recurrent Ovarian Epithelial Cancer; Recurrent Primary Peritoneal Cavity Cancer; Stage IIIA Fallopian Tube Cancer; Stage IIIA Ovarian Epithelial Cancer; Stage IIIA Primary Peritoneal Cavity Cancer; Stage IIIB Fallopian Tube Cancer; Stage IIIB Ovarian Epithelial Cancer; Stage IIIB Primary Peritoneal Cavity Cancer; Stage IIIC Fallopian Tube Cancer; Stage IIIC Ovarian Epithelial Cancer; Stage IIIC Primary Peritoneal Cavity Cancer; Stage IV Fallopian Tube Cancer; Stage IV Ovarian Epithelial Cancer; Stage IV Primary Peritoneal Cavity Cancer |
National Cancer Institute (NCI) |
2007-01 | PHASE2 |
| NCT00392444 | COMPLETED | Advanced Malignant Mesothelioma; Recurrent Malignant Mesothelioma |
National Cancer Institute (NCI) |
2007-02 | PHASE2 |
| NCT00698815 | COMPLETED | Recurrent Non-Small Cell Lung Carcinoma; Stage IIIB Non-Small Cell Lung Cancer AJCC v7; Stage IV Non-Small Cell Lung Cancer AJCC v7 |
National Cancer Institute (NCI) |
2008-04-15 | PHASE2 |
| NCT00400569 | COMPLETED | Liposarcoma; Leiomyosarcoma; Fibrosarcoma; Malignant Fibrous Histiocytoma |
H. Lee Moffitt Cancer Center and Research Institute |
2006-11 | PHASE2 |
| NCT00699374 | TERMINATED | Carcinoma, Hepatocellular |
Pfizer |
2008-07 | PHASE3 |
| NCT00480935 | TERMINATED | Renal Cell Carcinoma |
University Health Network, Toronto |
2007-10 | PHASE2 |
| NCT00931450 | UNKNOWN | Breast Cancer |
Institut Català d'Oncologia |
2009-03 | PHASE1; PHASE2 |
| NCT00879619 | TERMINATED | Prostate Cancer; Adenocarcinoma of the Prostate; Recurrent Prostate Cancer; Stage I Prostate Cancer; Stage III Prostate Cancer; Stage IV Prostate Cancer |
John P. Fruehauf |
2009-07 | PHASE1; PHASE2 |
| NCT00451048 | COMPLETED | Chronic Myelomonocytic Leukemia; de Novo Myelodysplastic Syndromes; Myelodysplastic Syndromes; Secondary Myelodysplastic Syndromes |
National Cancer Institute (NCI) |
2007-02 | PHASE2 |
| NCT00853372 | COMPLETED | Advanced Renal Cell Carcinoma |
Amgen |
2009-05-28 | PHASE2 |
| NCT00706706 | COMPLETED | Carcinoma, Renal Cell |
Pfizer |
2008-07 | PHASE4 |
| NCT00520533 | TERMINATED | Renal Cell Carcinoma (RCC) |
Ludwig Institute for Cancer Research |
2008-02 | PHASE1 |
| NCT00792025 | COMPLETED | Bladder Cancer; Transitional Cell Cancer of the Renal Pelvis and Ureter |
Institut Curie |
2008-12 | PHASE2 |
| NCT00330564 | TERMINATED | Von Hippel-Lindau Syndrome; Renal Cell Carcinoma; Hemangioblastoma |
M.D. Anderson Cancer Center |
2006-05 | PHASE2 |
| NCT00890747 | COMPLETED | Accelerated Phase Chronic Myelogenous Leukemia; Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome; Acute Undifferentiated Leukemia; Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Grade III Lymphomatoid Granulomatosis; Adult Langerhans Cell Histiocytosis; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Aggressive NK-cell Leukemia; AIDS-related Diffuse Large Cell Lymphoma; AIDS-related Diffuse Mixed Cell Lymphoma; AIDS-related Diffuse Small Cleaved Cell Lymphoma; AIDS-related Immunoblastic Large Cell Lymphoma; AIDS-related Lymphoblastic Lymphoma; AIDS-related Malignancies; AIDS-related Small Noncleaved Cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative; Chronic Eosinophilic Leukemia; Chronic Myelomonocytic Leukemia; Chronic Neutrophilic Leukemia; Chronic Phase Chronic Myelogenous Leukemia; Clear Cell Renal Cell Carcinoma; Cutaneous B-cell Non-Hodgkin Lymphoma; de Novo Myelodysplastic Syndromes; Essential Thrombocythemia; Extramedullary Plasmacytoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; HIV Infection; HIV-associated Hodgkin Lymphoma; Intraocular Lymphoma; Isolated Plasmacytoma of Bone; Light Chain Deposition Disease; Mast Cell Leukemia; Myelodysplastic Syndrome With Isolated Del(5q); Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Myeloid/NK-cell Acute Leukemia; Nodal Marginal Zone B-cell Lymphoma; Noncutaneous Extranodal Lymphoma; Osteolytic Lesions of Multiple Myeloma; Peripheral T-cell Lymphoma; Plasma Cell Neoplasm; Polycythemia Vera; Post-transplant Lymphoproliferative Disorder; Previously Treated Myelodysplastic Syndromes; Primary Myelofibrosis; Primary Systemic Amyloidosis; Progressive Hairy Cell Leukemia, Initial Treatment; Prolymphocytic Leukemia; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Renal Cell Cancer; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Refractory Multiple Myeloma; Relapsing Chronic Myelogenous Leukemia; Stage IV Renal Cell Cancer; T-cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific; Waldenström Macroglobulinemia |
National Cancer Institute (NCI) |
2009-08 | PHASE1 |
| NCT00859339 | TERMINATED | Transitional Cell Carcinoma of the Bladder |
Noah Hahn, M.D. |
2009-03 | PHASE2 |
| NCT00616122 | TERMINATED | Breast Cancer |
University of California, San Francisco |
2006-03-01 | PHASE1; PHASE2 |
| NCT00459979 | COMPLETED | Kidney Cancer |
Case Comprehensive Cancer Center |
2007-03 | PHASE2 |
| NCT00541008 | COMPLETED | Kidney Cancer |
UNICANCER |
2007-09-05 | PHASE2 |
| NCT00673816 | TERMINATED | Von Hippel-Lindau Syndrome |
National Eye Institute (NEI) |
2008-05 | PHASE1; PHASE2 |
| NCT00626509 | UNKNOWN | Kidney Cancer |
Gruppo Italiano Carcinoma Renale |
2008-02 | PHASE2 |
| NCT00814021 | COMPLETED | Kidney Cancer; Metastatic Cancer |
Institut Claudius Regaud |
2009-04 | PHASE2 |
| NCT01118039 | UNKNOWN | Bladder Cancer; Transitional Cell Cancer of the Renal Pelvis and Ureter; Urethral Cancer |
Hospital del Mar |
2006-07 | PHASE2 |
| NCT00524316 | TERMINATED | Liver Cancer |
Roswell Park Cancer Institute |
2007-04 | PHASE2 |
| NCT00495625 | TERMINATED | Liver Cancer |
H. Lee Moffitt Cancer Center and Research Institute |
2006-10 | PHASE2 |
| NCT00824538 | TERMINATED | Breast Cancer |
University of California, San Francisco |
2009-02 | PHASE2 |
| NCT00459875 | COMPLETED | Kidney Cancer |
Memorial Sloan Kettering Cancer Center |
2007-03 | PHASE2 |
| NCT00474994 | COMPLETED | Adult Malignant Fibrous Histiocytoma of Bone; Desmoid Tumor; Endometrial Cancer; Ovarian Cancer; Sarcoma; Small Intestine Cancer |
Memorial Sloan Kettering Cancer Center |
2007-04 | PHASE2 |
| NCT00521092 | WITHDRAWN | AIDS-related Kaposi Sarcoma; Classic Kaposi Sarcoma |
National Cancer Institute (NCI) |
2009-01 | PHASE2 |
| NCT00656669 | COMPLETED | Breast Cancer |
Indiana University |
2008-04 | |
| NCT00555620 | COMPLETED | Stomach Neoplasms |
Pfizer |
2008-05 | PHASE1 |
| NCT00425386 | COMPLETED | Kidney Cancer |
OHSU Knight Cancer Institute |
2006-08 | PHASE2 |
| NCT01024205 | COMPLETED | Kidney Cancer |
Barts and the London School of Medicine and Dentistry |
2007-08 | PHASE2 |
| NCT00717587 | UNKNOWN | Kidney Cancer |
Abramson Cancer Center at Penn Medicine |
2008-06 | PHASE2 |
| NCT00953459 | TERMINATED | Lung Cancer |
European Organisation for Research and Treatment of Cancer - EORTC |
2009-02 | PHASE2 |
| NCT00471276 | COMPLETED | Breast Neoplasms |
Pfizer |
2007-08 | PHASE2 |
| NCT00267748 | COMPLETED | Carcinoma, Renal Cell |
Pfizer |
2005-12 | PHASE2 |
| NCT00462553 | COMPLETED | Adenocarcinoma of the Pancreas; Recurrent Pancreatic Cancer; Stage III Pancreatic Cancer; Stage IV Pancreatic Cancer; Unspecified Adult Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2007-03 | PHASE1 |
| NCT00787787 | TERMINATED | Adult Primary Hepatocellular Carcinoma; Advanced Adult Primary Liver Cancer; Localized Unresectable Adult Primary Liver Cancer; Recurrent Adult Primary Liver Cancer |
University of Washington |
2008-09 | PHASE2 |
| NCT00936832 | WITHDRAWN | Colorectal Cancer; Metastatic Cancer |
Federation Francophone de Cancerologie Digestive |
2009-04 | PHASE2 |
| NCT00482755 | COMPLETED | Breast Cancer |
NCIC Clinical Trials Group |
2009-04-08 | PHASE2 |
| NCT00387335 | COMPLETED | Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity |
National Cancer Institute (NCI) |
2006-08 | PHASE2 |
| NCT00730353 | COMPLETED | Esophageal Cancer |
Hoosier Cancer Research Network |
2008-08 | PHASE2 |
| NCT00526656 | COMPLETED | Bladder Cancer |
Case Comprehensive Cancer Center |
2007-09 | PHASE2 |
| NCT00393939 | COMPLETED | Breast Neoplasms |
Pfizer |
2007-02 | PHASE3 |
| NCT00555672 | COMPLETED | Stomach Neoplasms |
Pfizer |
2008-08 | PHASE1 |
| NCT00662025 | COMPLETED | Advanced/Metastatic Breast Cancer |
Pfizer |
2008-04 | PHASE2 |
| NCT00372567 | TERMINATED | Gastrointestinal Stromal Tumor |
Pfizer |
2007-06 | PHASE3 |
| NCT00373113 | TERMINATED | Breast Neoplasms |
Pfizer |
2006-11 | PHASE3 |
| NCT00573404 | TERMINATED | Gastrointestinal Stromal Tumor |
Vanderbilt-Ingram Cancer Center |
2007-07 | PHASE1 |
| NCT00849186 | COMPLETED | Kidney Cancer |
Roswell Park Cancer Institute |
2007-08 | |
| NCT00417885 | TERMINATED | Breast Neoplasms |
Pfizer |
2007-06 | PHASE1; PHASE2 |
| NCT00411151 | COMPLETED | Gastric Adenocarcinoma; Barrett Esophagus |
Johannes Gutenberg University Mainz |
2006-12 | PHASE2 |
| NCT00599313 | COMPLETED | Metastatic Prostate Cancer |
US Oncology Research |
2007-03 | PHASE2 |
| NCT00499473 | COMPLETED | Adult Anaplastic Astrocytoma; Adult Diffuse Astrocytoma; Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Adult Mixed Glioma; Adult Oligodendroglioma; Adult Pineal Gland Astrocytoma |
National Cancer Institute (NCI) |
2007-06 | PHASE2 |
| NCT00338884 | COMPLETED | Carcinoma, Renal Cell |
Pfizer |
2006-09 | PHASE2 |
| NCT00482911 | TERMINATED | Intraocular Melanoma; Malignant Conjunctival Neoplasm |
National Institutes of Health Clinical Center (CC) |
2007-04 | PHASE2 |
| NCT00428597 | TERMINATED | Carcinoma, Islet Cell; Carcinoma, Pancreas |
Pfizer |
2007-06 | PHASE3 |
| NCT00514137 | COMPLETED | Refractory Multiple Myeloma; Stage I Multiple Myeloma; Stage II Multiple Myeloma; Stage III Multiple Myeloma |
National Cancer Institute (NCI) |
2007-09 | PHASE2 |
| NCT00389974 | COMPLETED | Cervical Adenocarcinoma; Cervical Adenosquamous Cell Carcinoma; Cervical Squamous Cell Carcinoma; Recurrent Cervical Cancer; Stage IVB Cervical Cancer |
National Cancer Institute (NCI) |
2007-01 | PHASE2 |
| NCT00387426 | TERMINATED | Accelerated Phase Chronic Myelogenous Leukemia; Acute Undifferentiated Leukemia; Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative; Blastic Phase Chronic Myelogenous Leukemia; Chronic Myelomonocytic Leukemia; Chronic Phase Chronic Myelogenous Leukemia; Mast Cell Leukemia; Meningeal Chronic Myelogenous Leukemia; Primary Myelofibrosis; Progressive Hairy Cell Leukemia, Initial Treatment; Prolymphocytic Leukemia; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Relapsing Chronic Myelogenous Leukemia; Secondary Acute Myeloid Leukemia; Stage I Chronic Lymphocytic Leukemia; Stage II Chronic Lymphocytic Leukemia; Stage III Chronic Lymphocytic Leukemia; Stage IV Chronic Lymphocytic Leukemia; T-cell Large Granular Lymphocyte Leukemia; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Adult Acute Myeloid Leukemia; Untreated Hairy Cell Leukemia |
National Cancer Institute (NCI) |
2006-09 | PHASE2 |
| NCT00399152 | COMPLETED | Renal Cancer; GIST |
AEterna Zentaris |
2006-10 | PHASE1 |
| NCT00444314 | COMPLETED | Metastatic Renal Cell Carcinoma |
CASI pharmaceuticals, Inc. |
2007-02 | PHASE2 |
| NCT00398112 | COMPLETED | B-cell Chronic Lymphocytic Leukemia; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia |
National Cancer Institute (NCI) |
2007-08 | PHASE2 |
| NCT00453310 | COMPLETED | Extragonadal Germ Cell Tumor; Ovarian Cancer; Teratoma; Testicular Germ Cell Tumor |
Memorial Sloan Kettering Cancer Center |
2007-03 | PHASE2 |
| NCT00462982 | COMPLETED | Kidney Cancer; Melanoma (Skin); Metastatic Cancer |
Memorial Sloan Kettering Cancer Center |
2007-03 | PHASE2 |
| NCT00457743 | COMPLETED | Gastrointestinal Stromal Tumors |
Pfizer |
2005-01 | PHASE1; PHASE2 |
| NCT00514228 | COMPLETED | Liver Cancer |
Swiss Cancer Institute |
2007-07 | PHASE2 |
| NCT00748163 | WITHDRAWN | Lung Cancer |
Masonic Cancer Center, University of Minnesota |
2008-08 | PHASE2 |
| NCT00402415 | TERMINATED | Tumors |
Yale University |
2006-02 | PHASE1 |
| NCT00397787 | COMPLETED | Acinar Cell Adenocarcinoma of the Pancreas; Duct Cell Adenocarcinoma of the Pancreas; Recurrent Pancreatic Cancer; Stage IV Pancreatic Cancer |
National Cancer Institute (NCI) |
2006-11 | PHASE2 |
| NCT00378911 | COMPLETED | Recurrent Uterine Sarcoma; Uterine Leiomyosarcoma |
National Cancer Institute (NCI) |
2006-10 | PHASE2 |
(data from https://clinicaltrials.gov, updated on 2026-06-12)
Check the
Sunitinib (SU11248) Malate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Mechanism and Biochemical Profile
Appendix RUO and cGMP Quality Standards
| Quality Dimension | RUO (Research Use Only) | cGMP (Current Good Manufacturing Practice) |
|---|---|---|
| Clinical Applicability | Prohibited in human clinical trials or medical diagnostics. | Mandatory for human clinical trials (Phase I–III) and therapies. |
| Regulatory Status | Non-regulated grade; exempt from drug manufacturing laws. | Legally enforced by health authorities (e.g., FDA, EMA, NMPA). |
| Facility Environment | Unclassified analytical or research laboratories. | Validated Cleanrooms (ISO Class 5–8) with continuous monitoring. |
| Quality Control | Basic purity and activity testing. | Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma). |
| Process Validation | Basic equipment calibration; no process validation required. | Full qualification (IQ/OQ/PQ) and complete batch records. |
| Quality Assurance | Vendor self-declared without required formal QMS. | Mandatory QA/QC unit, Change Control, CAPA, and vendor audits. |
| Regulatory Impact | High risk of IND rejection if used as a critical raw material. | Required for IND/NDA filings, supported by Drug Master Files (DMF). |
Footnotes
Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).
- Sunitinib (SU11248) Malate Solubility in DMSO
- Sunitinib (SU11248) Malate Stock Solution
- Sunitinib (SU11248) Malate Storage
- Sunitinib (SU11248) Malate Stability
- Sunitinib (SU11248) Malate Molecular Weight
- Sunitinib (SU11248) Malate SMILES
- Sunitinib (SU11248) Malate CAS Number
- Sunitinib (SU11248) Malate Chemical Structure (2D and 3D)
- Sunitinib (SU11248) Malate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.