CAS No. 122-11-2
Batch:
Purity:100
Chemical Structure
Check the
Sulphadimethoxine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 122-11-2 | |
|---|---|---|
| Molecular Formula |
C12H14N4O4S |
|
| Molecular Weight (MW) | 310.33 | |
| SMILES | COC1=NC(=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N)OC |
Biological Activity
Sulphadimethoxine is a long-acting sulfonamide antimicrobial agent that functions as a competitive inhibitor of bacterial dihydropteroate synthase (DHPS). By competing with para-aminobenzoic acid (PABA) for active site binding on DHPS, it selectively disrupts the essential bacterial folate biosynthesis pathway. This enzymatic blockade suppresses purine and pyrimidine nucleotide synthesis, ultimately leading to the inhibition of bacterial DNA replication and cell growth. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
62 mg/mL
(199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.