CAS No. 2451481-08-4
Batch:
Purity:99.91
Chemical Structure
Check the
Sulfopin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-chloro-N-(2,2-dimethylpropyl)-N-(1,1-dioxothiolan-3-yl)acetamide | |
|---|---|---|
| CAS Number | 2451481-08-4 | |
| Molecular Formula |
C11H20ClNO3S |
|
| Molecular Weight (MW) | 281.80 | |
| SMILES | CC(C)(C)CN(C1CC[S](=O)(=O)C1)C(=O)CCl | |
| InChIKey | NMHVAHHYKGXBMY-UHFFFAOYSA-N |
Sulfopin is a selective covalent inhibitor of Pin1. By covalently modifying Pin1, Sulfopin disrupts Pin1-mediated conformational changes and downregulates Myc-driven gene expression and oncogenic signaling pathways, leading to reduced cancer cell proliferation. Consequently, this targeted small molecule effectively blocks Myc-driven tumor initiation and progression in vivo across preclinical cancer models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
56 mg/mL
(198.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 28 mg/mL |
| Water | 3 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.