CAS No. 1308672-74-3

Batch: Purity:99.04
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Sulfatinib Chemical Structure
Chemical Structure
Check the Sulfatinib product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[2-(dimethylamino)ethyl]-1-[3-[[4-[(2-methyl-1H-indol-5-yl)oxy]pyrimidin-2-yl]amino]phenyl]methanesulfonamide
CAS Number 1308672-74-3
Molecular Formula

C24H28N6O3S
Molecular Weight (MW) 480.58
SMILES CC1=CC2=C(N1)C=CC(=C2)OC3=NC(=NC=C3)NC4=CC=CC(=C4)CS(=O)(=O)NCCN(C)C
InChIKey TTZSNFLLYPYKIL-UHFFFAOYSA-N

Ordering Information

Biological Activity

Sulfatinib is a potent, selective tyrosine kinase inhibitor targeting VEGFR1, VEGFR2, VEGFR3, FGFR1, and CSF1R. By concurrently blocking VEGFR and FGFR pathways alongside CSF1R signaling, it suppresses receptor auto-phosphorylation, impairs tumor angiogenesis, and inhibits macrophage-mediated tumor immune evasion. These actions disrupt vascular endothelial cell survival, impair tumor cell proliferation, and modulate the tumor microenvironment to suppress tumor growth.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 145 mg/mL (301.71 mM) ; Warmed with 60°C water bath ; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.