CAS No. 1981-58-4

Batch: Purity:98
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Sulfamethazine Sodium Salt Chemical Structure
Chemical Structure
Check the Sulfamethazine Sodium Salt product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name sodium (4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide
CAS Number 1981-58-4
Molecular Formula

C12H13N4O2S.Na
Molecular Weight (MW) 300.31
SMILES CC1=CC(=NC(=N1)[N-]S(=O)(=O)C2=CC=C(C=C2)N)C.[Na+]
InChIKey NGIVTUVVBWOTNT-UHFFFAOYSA-N

Biological Activity

Sulfamethazine sodium salt is a sulfonamide anti-infective agent that targets bacterial dihydropteroate synthase (DHPS). By competing with p-aminobenzoic acid, it inhibits enzymatic activity within the folic acid synthesis pathway, blocking essential folate cofactor production. This disruption impairs bacterial nucleic acid synthesis, ultimately arresting bacterial proliferation and cell growth across susceptible bacterial strains. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 60 mg/mL (199.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Achari A, et al. Nat Struct Biol. 1997;4(6):490-7.

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Note: Technical data last updated: Sep 1, 2026.