CAS No. 6209-17-2

Batch: Purity:99.77
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Sulfacetamide sodium salt hydrate Chemical Structure
Chemical Structure
Check the Sulfacetamide sodium salt hydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 6209-17-2
Molecular Formula

C8H9N2O3S.H2O.Na
Molecular Weight (MW) 254.24
SMILES CC(=O)[N-]S(=O)(=O)C1=CC=C(C=C1)N.O.[Na+]

Biological Activity

Sulfacetamide sodium salt hydrate is a sulfonamide antibiotic that targets dihydropteroate synthase (DHPS). As a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), it impairs DHPS activity to block dihydrofolic acid synthesis within the folic acid pathway. This disruption inhibits bacterial purine and pyrimidine biosynthesis, ultimately suppressing essential nucleic acid production and bacterial growth.

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 50 mg/mL (196.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 50 mg/mL
Ethanol 2 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.