CAS No. 69388-84-7
| IUPAC Name | sodium (2S,5R)-3,3-dimethyl-4,4,7-trioxo-4λ6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate | |
|---|---|---|
| CAS Number | 69388-84-7 | |
| Molecular Formula |
C8H10NO5S.Na |
|
| Molecular Weight (MW) | 255.22 | |
| SMILES | CC1(C(N2C(S1(=O)=O)CC2=O)C(=O)[O-])C.[Na+] | |
| InChIKey | NKZMPZCWBSWAOX-IBTYICNHSA-M |
Sulbactam sodium is an irreversible β-lactamase inhibitor that restores the antibacterial efficacy of β-lactam antibiotics against resistant bacterial strains. By irreversibly binding to active-site serine residues of β-lactamases, sulbactam prevents the enzymatic degradation of penicillins and cephalosporins. This targeted inactivation preserves β-lactam integrity, leading to effective disruption of bacterial cell wall peptidoglycan synthesis and suppression of bacterial growth. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| Water | 51 mg/mL |
| DMSO |
3 mg/mL
(11.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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