CAS No. 1055412-47-9
Batch:
Purity:99.77
Chemical Structure
Check the
SU5614
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3Z)-5-chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one | |
|---|---|---|
| CAS Number | 1055412-47-9 | |
| Molecular Formula |
C15H13ClN2O |
|
| Molecular Weight (MW) | 272.73 | |
| SMILES | CC1=CC(=C(N1)C=C2C3=C(C=CC(=C3)Cl)NC2=O)C | |
| InChIKey | XLBQNZICMYZIQT-GHXNOFRVSA-N |
SU5614 is a receptor tyrosine kinase inhibitor targeting VEGFR-2, c-Kit, and both wild-type and mutant FLT3. By suppressing RTK phosphorylation, SU5614 inhibits downstream oncogenic signaling cascades in leukemia and other transformed cells. This pathway block disrupts cell survival and growth, ultimately leading to reduced cell proliferation and the induction of apoptosis. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
10 mg/mL
(36.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
10 mg/mL
(36.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.