CAS No. 186611-04-1
Batch:
Purity:98.67
Chemical Structure
Check the
SU5214
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3Z)-3-[(2-methoxyphenyl)methylidene]-1H-indol-2-one | |
|---|---|---|
| CAS Number | 186611-04-1 | |
| Molecular Formula |
C16H13NO2 |
|
| Molecular Weight (MW) | 251.28 | |
| SMILES | COC1=CC=CC=C1C=C2C3=CC=CC=C3NC2=O | |
| InChIKey | NEQZEVOPIKSAJP-RAXLEYEMSA-N |
SU5214 is a receptor tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2 (VEGFR2/FLK-1) and epidermal growth factor receptor (EGFR). By blocking VEGFR2 and EGFR catalytic activity, SU5214 disrupts downstream receptor autophosphorylation and intracellular signaling cascades. This inhibition suppresses endothelial cell proliferation, migration, and capillary-like tube formation while impairing growth factor-driven tumor angiogenesis. Consequently, SU5214 attenuates cellular survival and vascular sprout formation.
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
50 mg/mL
(198.98 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.