CAS No. 3476-86-6
Batch:
Purity:98.89
Chemical Structure
Check the
SU5205
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3Z)-3-[(4-fluorophenyl)methylidene]-1H-indol-2-one | |
|---|---|---|
| CAS Number | 3476-86-6 | |
| Molecular Formula |
C15H10FNO |
|
| Molecular Weight (MW) | 239.24 | |
| SMILES | C1=CC=C2C(=C1)C(=CC3=CC=C(C=C3)F)C(=O)N2 | |
| InChIKey | QIERHADIMMFZNE-LCYFTJDESA-N |
SU5205 is a small-molecule inhibitor targeting vascular endothelial growth factor receptor 2 (VEGFR2/FLK-1). By suppressing VEGFR2 tyrosine kinase activity, SU5205 disrupts downstream VEGF receptor signaling pathways, leading to the inhibition of endothelial cell proliferation, survival, and capillary tube formation. Consequently, this block in VEGFR2-mediated signaling suppresses angiogenesis and reduces microvessel formation in cellular models.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
48 mg/mL
(200.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.