CAS No. 4312-32-7
Batch:
Purity:99.95
Chemical Structure
Check the
Stylopine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5,7,17,19-tetraoxa-13-azahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-2,4(8),9,15(23),16(20),21-hexaene | |
|---|---|---|
| CAS Number | 4312-32-7 | |
| Molecular Formula |
C19H17NO4 |
|
| Molecular Weight (MW) | 323.34 | |
| SMILES | C1OC2=CC3=C(C=C2O1)C4CC5=CC=C6OCOC6=C5CN4CC3 | |
| InChIKey | UXYJCYXWJGAKQY-UHFFFAOYSA-N |
Stylopine, a natural isoquinoline alkaloid derived from Chelidonium majus L., acts as a potent anti-inflammatory compound. It suppresses lipopolysaccharide-induced production of nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6). Downstream, stylopine inhibits cyclooxygenase-2 (COX-2) activity and inducible nitric oxide synthase expression, thereby suppressing NF-kB-mediated inflammatory signaling cascades and downstream cellular inflammatory responses. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
2.5 mg/mL
(7.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.