CAS No. 96087-21-7

Batch: Purity:99.95
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Stylopine hydrochloride Chemical Structure
Chemical Structure
Check the Stylopine hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 96087-21-7
Molecular Formula

C19H18ClNO4
Molecular Weight (MW) 359.8
SMILES C1C[NH+]2CC3=C(CC2C4=CC5=C(C=C41)OCO5)C=CC6=C3OCO6.[Cl-]

Ordering Information

Biological Activity

Stylopine hydrochloride (tetrahydrocoptisine) is a protoberberine-type alkaloid derived from Chelidonium majus L. with anti-inflammatory activity. It suppresses the expression and release of key pro-inflammatory mediators, including nitric oxide, TNF-α, and IL-6, in lipopolysaccharide-stimulated macrophages. These biological responses are mediated through the inhibition of the NF-kB and MAPK signaling pathways, leading to downstream reduction of cellular inflammatory phenotypes.

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 5 mg/mL (13.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.